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Recent studies have demonstrated that Lama4 affects endothelial cell tightness, increases leukocyte extravasation, and promotes monocyte-to-macrophage differentiation (38)

[1] [2] This medication works by mimicking the action of endogenous GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

Above all else, remember that semaglutide is a band-aid for insulin resistance, not a cure

John J.W

Some clinicians have adopted this reasoning and prescribe both medications off-label, particularly phentermine combined with semaglutide or phentermine combined with tirzepatide